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If the address matches an existing account you will receive an email with instructions to reset your password. If the address matches an existing account you will receive an email with instructions to retrieve your username. Search for more papers by this author. When mesenchymal stem cells MSCs are used for therapy of immunological pathologies, they get into an inflammatory environment, altering the effectiveness of the treatment. To establish the impact of environmental inflammatory factors on MSCs' immunofunction in the mirror of intrinsic heterogeneity of mouse MSC population, individual MSC clones were generated and characterized.
Adipogenic but not osteogenic differentiation and pro-angiogenic activity of five independent MSC cell lines were similar. To study the immunosuppressive heterogeneity, in vitro and in vivo experiments have been carried out using T-cell proliferation assay and delayed-type hypersensitivity DTH response, respectively.
Nevertheless, the differences between the immunosuppressive activities of the individual clones disappeared on pretreatment of the cells with pro-inflammatory cytokines, a procedure called licensing. The earlier findings were also supported by in vivo results. In contrast, prestimulation of MSC6 with inflammatory cytokines resulted in strong suppression by this clone as well.
Here, we have showed that MSC population is functionally heterogeneous in terms of immunosuppressive function; however, this variability is largely reduced under pro-inflammatory conditions.
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Request Username Can't sign in? Forgot your username? Enter your email address below and we will send you your username. Stem Cells and Development Vol.
View article. Mesenchymal stem cell therapy in acute kidney injury AKI : review and perspectives. Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies. Effect of allogeneic platelet lysate on equine bone marrow derived mesenchymal stem cell characteristics, including immunogenic and immunomodulatory gene expression profile. Role of Obesogens in the Pathogenesis of Obesity. Clearance of apoptotic cells by mesenchymal stem cells contributes to immunosuppression via PGE2.
Single cell transcriptomic analysis of human mesenchymal stem cells reveals limited heterogeneity. Immunomodulatory plasticity of mesenchymal stem cells: a potential key to successful solid organ transplantation. Inflammatory licensed equine MSCs are chondroprotective and exhibit enhanced immunomodulation in an inflammatory environment.
Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases. The immunomodulatory function of equine MSCs is enhanced by priming through an inflammatory microenvironment or TLR3 ligand.
Systemic lupus erythematosus in the light of the regulatory effects of galectin-1 on T-cell function. Effects of cell type and configuration on anabolic and catabolic activity in 3D co-culture of mesenchymal stem cells and nucleus pulposus cells. DSP30 enhances the immunosuppressive properties of mesenchymal stromal cells and protects their suppressive potential from lipopolysaccharide effects: A potential role of adenosine. Galectin-1 is a local but not systemic immunomodulatory factor in mesenchymal stromal cells.
Homing and migration of mesenchymal stromal cells: How to improve the efficacy of cell therapy? Volume 24 Issue 18 Sep Stem Cells and Development. Sep Close Figure Viewer. Previous Figure Next Figure.
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