Geenes V, Williamson C. Intrahepatic cholestasis of pregnancy. World J. Gastroenterol may 7;15 17 Kondrackiene J, Kupcinskas L.
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No se han descrito efectos adversos.. Ursodeoxycholic acid, used in the treatment of in-trahepatic cholestasis present in the chronic liver diseases such as, primary biliary cirrhosis, primary sclerosing cholangitis or chronic hepatitis, is contra-indicated in pregnant women as there are no studies of its use in pregnancy..
In both cases, pruritus regressed completely after 3 days of treatment and plasma levels of biliary acid and transaminases began to decrease. Both infants, born between the 37th and 38th weeks, were normal.. Of these 18 cases were in 2 randomised studies. In 49 cases pruritus had generally disappeared 3 days after the start of treatment and plasma levels of biliary acids and transami-nases decreased in one week.
Only two patients experienced persistent pruritus, although the biological criteria of cholestasis had decreased. No foetal teratogenicity or toxicity was observed.. Ursodeoxycholic acid seems to be an efficient treatment of gravid cholestasis. Long term observation of children exposed to this treatment in utero are required to confirm its apparent foetal safety.. ISSN: X.
Descargar PDF. Moro , A. Teijelo , F. Benavente , F. Corredera , A. Hospital Virgen de la Vega. No se han descrito efectos adversos. Ursodeoxycholic acid, used in the treatment of in-trahepatic cholestasis present in the chronic liver diseases such as, primary biliary cirrhosis, primary sclerosing cholangitis or chronic hepatitis, is contra-indicated in pregnant women as there are no studies of its use in pregnancy.
Both infants, born between the 37th and 38th weeks, were normal. No foetal teratogenicity or toxicity was observed. Long term observation of children exposed to this treatment in utero are required to confirm its apparent foetal safety. Acta Med Scand, , pp. Fallon, C.
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